Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Α-MSH (TFA) | 171869-93-5 | 98.5% | 25 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide that acts as a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities, being a post-translational derivative of pro-opiomelanocortin (POMC).
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells.
- Modulates NFκB activation.
- Inhibits translocation of transcription factor κB to the nucleus.
- Effectively modulates inflammatory reactions when given systemically.
TARGETMOL CHEMICALS INC Elarofiban TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease. Purity 100%
Medchemexpress LLC Psalmotoxin 1 TFA | 880107-52-8 | 99.37% | 4689.39 | 500 UG
Psalmotoxin 1 is a protein toxin that binds at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). It acts as a potent and selective ASIC1a inhibitor by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis and inhibit cell migration, proliferation, and invasion of cancer cells. It is utilized in research concerning cancers and neurological diseases.
- Potent and selective ASIC1a inhibitor with an IC50 of 0.9 nM
- Induces cell apoptosis
- Inhibits cell migration, proliferation, and invasion of cancer cells
- Used in research concerning cancers and neurological diseases
- Neuroprotective in a conscious model of stroke
- Inhibits tumor growth in breast cancer models
Medchemexpress LLC W1131 TFA 10mM | 2740522-79-4 | C₂₅H₂₀F₃NO₈ | 1 ML
W1131 TFA is a potent STAT3 inhibitor and ferroptosis inducer. It demonstrates anti-cancer properties by inhibiting tumor growth and alleviating chemoresistance in gastric cancer models. W1131 TFA regulates critical cellular processes including the cell cycle, DNA damage response, and oxidative phosphorylation, specifically impacting the IL6-JAK-STAT3 and ferroptosis pathways.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Modulates oxidative phosphorylation
- Impacts IL6-JAK-STAT3 pathway
- Affects ferroptosis pathway
Medchemexpress LLC GRGDSP TFA | 98.0% | 701.61 | 25 MG
GRGDSP (TFA) is an integrin inhibitor. This synthetic linear RGD peptide can inhibit the adherence of tumor cells to endothelial cells of blood vessels, thereby limiting metastasis. It is also utilized to modify the surface of cardiovascular implants, such as vascular grafts, to promote endothelialization, and is widely employed in integrin research as a soluble integrin-blocking RGD-based peptide.
- Inhibits adherence of tumor cells to endothelial cells of blood vessels
- Limits metastasis
- Promotes endothelialization for cardiovascular implants
- Used in integrin research
- Functions as a soluble integrin-blocking RGD-based peptide
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 5 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q type Ca2+ (Cav2.1) channels. It exhibits IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels. The compound inhibits glutamate exocytosis and calcium influx, as well as the release of serotonin and norepinephrine, when elicited by high potassium. It does not affect L-type or N-type calcium channels.
- Potent and selective P/Q type Ca2+ (Cav2.1) channel blocker.
- IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels.
- Inhibits glutamate exocytosis and calcium influx.
- Blocks high potassium-induced release of serotonin and norepinephrine.
- Has no effect on L-type or N-type calcium channels.
Medchemexpress LLC Men 10376 TFA | 99.7% | 1195.25 | 5 MG
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist. It exhibits a Ki of 4.4 μM for the rat small intestine NK-2 receptor, with low selectivity for NK-1 and NK-3 receptors. This compound antagonizes increases in bladder motility produced by NK-2 receptor agonists in rats.
- Selective tachykinin NK-2 receptor antagonist
- Ki of 4.4 μM for rat small intestine NK-2 receptor
- Low selectivity for NK-1 and NK-3 receptors (Ki >10 μM)
- Antagonizes bladder motility increase in vivo
Medchemexpress LLC MANS peptide TFA | 99.9% | 2498.83 (free acid) | 1 MG
MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). It is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.
- Inhibits migration and invasion of lung cancer cells (CL1-0/F3, CL1-5, PC9, A549) without causing toxicity to normal cells.
- Inhibits MARCKS phosphorylation and PI3K, AKT phosphorylation, leading to downstream changes in Slug and E-cadherin expression levels.
- Prevents the loss of cell-cell adhesion and alters epithelial-mesenchymal transition (EMT) characteristics of cancer cells, thereby decreasing tumor metastasis.
- Inhibits tumor metastasis without affecting tumorigenesis in PC9 xenograft NOD/SCID mice model.
Medchemexpress LLC Ql9 tfa | 95.91% | 5 MG
QL9 (QLSPFPFDL) TFA is a high-affinity alloantigen for the 2C T cell receptor (TCR), intended for research use only.
- High-affinity alloantigen
- Specific for the 2C T cell receptor (TCR)
- Suitable for research applications
Medchemexpress LLC LIH383 TFA | 2866266-58-0 | 99.8% | 997.22 | 5 MG
LIH383 TFA is a white to off-white solid that has been tested and complies with specifications, exhibiting a high purity of 99.83% by HPLC.
- Tested and complies with specifications
- High purity of 99.83% (HPLC)
- White to off-white solid appearance
- Store in sealed conditions away from moisture
- Powder stable for 2 years at -80°C or 1 year at -20°C
- In solvent, stable for 6 months at -80°C or 1 month at -20°C
Medchemexpress LLC Dota-octreotide tfa | 99.3% | 1519.66 | 1 MG
DOTA-Octreotide TFA is composed of the chelator DOTA and Octreotide (HY-P0036). It is utilized for cancer research through its combination with radioactive elements and can be employed for the synthesis and research of Radionuclide-Drug Conjugates (RDCs). Its molecular formula is C67H93F3N14O19S2 with a molecular weight of 1519.66. It appears as a white to off-white solid.
- Used for cancer research
- Combines with radioactive elements
- Can be used for synthesis and research of radionuclide-drug conjugates (RDCs)
- Soluble in H2O at ≥ 50 mg/mL (32.90 mM)
- Powder stable for 2 years at -80°C and 1 year at -20°C
- Solution stable for 6 months at -80°C and 1 month at -20°C
Medchemexpress LLC Vh4127 TFA | 1034.35 (free base) | 1 MG
VH4127 TFA is a cyclic peptide that targets the low-density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. It specifically binds to the epidermal growth factor (EGF) homology domain of both rodent and human LDLR.
- Targets low density lipoprotein receptor (LDLR)
- Has a high binding affinity (KD of 18 nM) for human LDLR
- Binds specifically to the EGF homology domain of rodent and human LDLR
- Available in various quantities
- For research use only
- Information on solubility, in vivo dissolution, and related antibodies is also available
Medchemexpress LLC Vh4127 TFA | 1034.35 (free base) | 5 MG
VH4127 TFA is a cyclic peptide that targets the low-density lipoprotein receptor (LDLR) with a KD of 18 nM for human LDLR. It specifically binds to the rodent and human epidermal growth factor (EGF) homology domain of LDLR. It is intended for research use only.
- Targets the low density lipoprotein receptor (LDLR)
- High affinity with a KD of 18 nM for human LDLR
- Specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR
- Documentation: data sheet and handling instructions are available
- Formulation: supplied as a solid
- For research use only
Medchemexpress LLC Parasin I TFA | 219552-69-9 | 99.8% | 2114.33 | 5 MG
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, exhibiting antimicrobial activity. It is intended for research use only and not for patient administration.
- 19-amino acid histone H2A-derived peptide
- Isolated from the skin of catfish
- Shows antimicrobial activity
- White to off-white solid appearance
- Sequence: Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser
- Initial source: Animals, the skin mucus of wounded catfish
Medchemexpress LLC Kisspeptin 13 TFA | 98.9% | 1626.81 | 1 MG
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). It inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. This compound interacts with α2-adrenergic and 5-HT2 serotonin receptors and exhibits antidepressant efficacy. It is an activator for GPR54 and GnRH receptor, enhancing memory and being useful in Alzheimer's disease research.
- Inhibits glucose-induced insulin secretion (IC50 of 1.2 nM)
- Activates hypothalamic-pituitary-adrenal (HPA) axis
- Causes hyperthermia, motor behavior and anxiety in rats
- Interacts with α2-adrenergic and 5-HT2 serotonin receptors
- Exhibits antidepressant efficacy
- Activator for GPR54 and GnRH receptor
- Enhances memory
- Useful in Alzheimer's disease research