Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
![Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000397365.png-250.jpg)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue.
- Acts as a GnRH receptor agonist.
Medchemexpress LLC PBX-7011 TFA | 3003834-30-5 | 98.6% | 561.46 | 1 ML
PBX-7011 TFA is a derivative of camptothecin that inhibits the expression of cancer-related survival genes and degrades DDX5 proteins.
- Inhibits expression of cancer-related survival genes (DDX5, Survivin, Mcl-1, and XIAP in FaDu cells).
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC UNC4976 trifluoroacetate | 98.0% | 961.12 g/mol | C49H71F3N6O10 | 5 MG
UNC4976 TFA is the trifluoroacetate salt of UNC4976, a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain that modulates chromodomain-nucleic acid interactions. It is supplied as a purified research compound intended for in vitro studies in epigenetics and chromatin biology.
- Trifluoroacetate salt form for improved handling and stability.
- High purity suitable for research applications (98.0%).
- Molecular formula C49H71F3N6O10 and molecular weight 961.12 g/mol.
- Available in small pack sizes for screening and assay development.
- Suitable for use in studies of chromodomain function and epigenetic modulation.
- Provided with documentation specifying identity and purity.
Medchemexpress LLC Bibo3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g·mol⁻¹ | C31H36F3N7O5 | 10 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used in pharmacological and receptor biology research. Supplied as a trifluoroacetate salt in solid form, it is characterized by a defined molecular formula and molecular weight and is intended for in vitro and in vivo experimental applications.
- Potent NPY Y1 receptor antagonist with subnanomolar affinity.
- High reported purity suitable for research-grade assays.
- Stable solid trifluoroacetate salt for convenient handling and storage.
- Available in small milligram quantities and pre-made DMSO solutions for assay readiness.
- Characterized molecular weight and formula to support analytical and dosing calculations.
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.1% | 2675.03 | 2 MG
KRpep-2d is a potent inhibitor of K-Ras, designed to impede the proliferation of K-Ras-driven cancer cells. It is suitable for use in cancer research. The product possesses a cyclic structure, which is crucial for its K-Ras inhibitory activity, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for this function.
- Potently inhibits K-Ras activity.
- Reduces the proliferation of cancer cells driven by K-Ras.
- Features a cyclic structure important for its inhibitory action.
- Critical amino acid residues contribute to its effectiveness.
- Can be used for cancer research applications.
Medchemexpress LLC Nangibotide TFA | 99.36% | 1457.46 | 1 MG
Nangibotide TFA (LR12 TFA) is a synthetic peptide and a TREM-1 receptor inhibitor. It inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors such as IL-1β and IL-8. This peptide also inhibits apoptosis, reducing excessive inflammatory responses and protecting tissues from damage. It can be used in research for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure.
- Inhibits NF-κB and NLRP3 inflammasome activation
- Reduces release of pro-inflammatory factors like IL-1β and IL-8
- Protects tissues (liver, lung) from damage
- Can be used in research for various inflammatory and injury conditions
Medchemexpress LLC FStAx-35R TFA | 97.4% | 2885.36 (free base) | 1 MG
fStAx-35R TFA is a hydrocarbon-stapled peptide that inhibits the Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. It can be utilized in cancer research.
- Inhibits Wnt/β-catenin signaling pathway
- Disrupts β-catenin-TCF interaction
- Suitable for cancer research
Medchemexpress LLC Pam3CSK4 (TFA) | 112208-01-2 | 99.9% | 1852.30 | 25 MG
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist, demonstrating an EC50 of 0.47 ng/mL for human TLR1/2. This compound is a TLR1/2 heterodimer that specifically recognizes triacylated lipopeptides. It has been shown to enhance the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils against Methicillin-resistant Staphylococcus aureus (MRSA).
- Acts as a TLR1/2 agonist
- Effective at an EC50 of 0.47 ng/mL for human TLR1/2
- Recognizes triacylated lipopeptides
- Enhances antibacterial functions of GM-CSF induced neutrophils
- For research use only
- Appears as a white to off-white solid
Medchemexpress LLC Balixafortide TFA (POL6326 TFA) | 1051366-32-5 | 99.9% | 1978.16 | 25 MG
Balixafortide TFA (POL6326 TFA) is a potent, selective, and well-tolerated peptidic CXCR4 antagonist with an IC50 less than 10 nM. It demonstrates significant selectivity for CXCR4, approximately 1000-fold, over various other receptors including CXCR7. This compound effectively blocks β-arrestin recruitment and calcium flux with IC50s less than 10 nM, functioning as a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent with observed anti-cancer effects.
- Potent and selective CXCR4 antagonist
- Demonstrates high selectivity over other receptors like CXCR7
- Blocks β-arrestin recruitment and calcium flux
- Functions as a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent
- Exhibits anti-cancer effects
- Optimized for favorable mouse ADME properties
Medchemexpress LLC Gln-AMS TFA | 209543-57-7 | >99.85% | 588.47 | 1 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is for research use only.
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM
![Medchemexpress LLC L-prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl] TFA | 157379-44-7 | 99.3% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232164.png-250.jpg)
Medchemexpress LLC L-prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl] TFA | 157379-44-7 | 99.3% | 25 MG
PPACK (TFA) is the trifluoroacetate salt of a peptide-based irreversible thrombin inhibitor supplied as a white to off-white solid. It is used in biochemical assays to inhibit thrombin activity and for anticoagulation research.
- Irreversible thrombin inhibitor for biochemical assays.
- High purity of 99.3% as determined by HPLC.
- White to off-white solid form suitable for storage and handling.
- Recommended storage conditions for powder and solvent are provided in the COA.
- Molecular weight 564.99 and formula C23H32ClF3N6O5.
Medchemexpress LLC 4,7,10,13,16-pentaazanonadecanedioic acid ester (TFA) | MFCD34677028 | 98.6% | 1841.72 (free base) | C93H173N5O20S5·xC2HF3O2 | 5 MG
5A2-SC8 TFA is an ionizable amino lipid provided as the trifluoroacetic acid salt for formulation into lipid nanoparticles (LNPs). It is intended for research use to enable efficient delivery of small RNAs, such as siRNA and miRNA, and has documented low in vivo toxicity and COA-verified purity.
- Ionizable amino lipid suitable for LNP formulation.
- Enhances delivery of siRNA and miRNA to target cells.
- Low in vivo toxicity profile reported.
- Provided as the TFA salt to aid formulation and handling.
- COA-verified purity by HPLC (~98.6%).
- Store at -80 °C and protect from light for stability.